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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IQGAP2
All Species:
16.06
Human Site:
S591
Identified Species:
39.26
UniProt:
Q13576
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13576
NP_006624.2
1575
180578
S591
V
K
A
K
E
L
K
S
E
R
V
S
S
D
G
Chimpanzee
Pan troglodytes
XP_001146396
1575
180717
S591
V
K
A
K
E
L
K
S
E
R
V
S
S
D
G
Rhesus Macaque
Macaca mulatta
XP_001114017
1632
184597
K662
L
E
G
A
M
A
K
K
Q
R
P
A
D
S
A
Dog
Lupus familis
XP_536318
1641
188145
S657
A
K
A
K
E
H
K
S
K
S
V
S
A
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q3UQ44
1575
180509
T591
V
K
A
K
E
S
K
T
D
N
E
S
S
E
G
Rat
Rattus norvegicus
NP_001101959
1657
188814
L676
A
E
A
K
K
K
R
L
A
A
G
D
N
N
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_413959
2023
228609
M1042
V
E
V
K
R
R
K
M
A
T
G
G
N
G
S
Frog
Xenopus laevis
NP_001082588
1660
189688
T674
C
E
D
K
K
Q
K
T
T
E
D
V
D
E
S
Zebra Danio
Brachydanio rerio
NP_001121812
1680
191619
T686
H
Q
L
Q
S
T
Q
T
Q
Q
G
T
S
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001203784
771
87814
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
50.3
86.7
N.A.
88.9
58.2
N.A.
N.A.
48.7
66.6
61.4
N.A.
N.A.
N.A.
N.A.
25.2
Protein Similarity:
100
99.8
69
91.5
N.A.
95.3
74.7
N.A.
N.A.
61.5
78
75.8
N.A.
N.A.
N.A.
N.A.
38.3
P-Site Identity:
100
100
13.3
60
N.A.
60
13.3
N.A.
N.A.
20
13.3
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
40
80
N.A.
80
46.6
N.A.
N.A.
33.3
40
53.3
N.A.
N.A.
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
50
10
0
10
0
0
20
10
0
10
10
0
10
% A
% Cys:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
0
0
0
10
0
10
10
20
20
0
% D
% Glu:
0
40
0
0
40
0
0
0
20
10
10
0
0
30
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
0
0
0
0
0
0
0
30
10
0
20
40
% G
% His:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
40
0
70
20
10
70
10
10
0
0
0
0
0
0
% K
% Leu:
10
0
10
0
0
20
0
10
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
10
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
20
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% P
% Gln:
0
10
0
10
0
10
10
0
20
10
0
0
0
0
0
% Q
% Arg:
0
0
0
0
10
10
10
0
0
30
0
0
0
0
0
% R
% Ser:
0
0
0
0
10
10
0
30
0
10
0
40
40
10
40
% S
% Thr:
0
0
0
0
0
10
0
30
10
10
0
10
0
0
0
% T
% Val:
40
0
10
0
0
0
0
0
0
0
30
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _